Provided is a safe vaccine for mycoplasma infection with high therapeutic effect and a method for effectively treating mycoplasma infection. Also provid is an effective pseudo-mycoplasma particle and a pseudo-bacteria particle including general bacteria as a vaccine for mycoplasma infection disease.In this application, a pseudo-bacteria particle such as pseudo-mycoplasma particle etc. can be provided by making a liposome particle comprising the lipid antigen being specific to pathogenic bacteria such as mycoplasma etc. as the lipid component of liposome. By administrating the pseudo-mycoplasma particle, a strong immune activity in vivo can be induced, thus provides an excellent vaccine for preventing or treating the mycoplasma infection disease.本發明之目的係提供對於黴漿菌感染症治療效果高且安全的疫苗，及開發有效的黴漿菌感染症的治療方法，並以提供有效的擬似黴漿菌粒子，以及包含一般細菌的擬似細菌粒子作為黴漿菌感染症用疫苗為目的。於本發明，經由作成含有對黴漿菌等病原性細菌為特異性的脂質抗原作為構成微脂體脂質成分的微脂體粒子，可提供擬似黴漿菌粒子等的擬似細菌粒子。投予該擬似黴漿菌粒子，在生體內可誘導強的免疫活性，而可提供優越的黴漿菌感染症的預防用或治療用疫苗。
