An oral care implement having an arrangement of tooth cleaning elements thereon. The oral care implement may include a head extending from a proximal end to a distal end and comprising first and second peripheral sides. A plurality of tooth cleaning elements extend from the head and are arranged in groups including a first peripheral grouping of tooth cleaning elements positioned adjacent the first peripheral side of the head and having first and second types of tooth cleaning elements, a distal grouping of tooth cleaning elements positioned adjacent the distal end of the head and having a third type of tooth cleaning element, and a proximal grouping of tooth cleaning elements positioned adjacent the proximal end of the head and having the third type of tooth cleaning element. The first, second, and third types of tooth cleaning elements are different in at least one more structural characteristics.