VITT, DANIEL,GROEPPEL, MANFRED,BAUMGARTNER, ROLAND,LEBAN, JOHANN
申请号：
PE0019002011
公开号：
PE08982012A1
申请日:
2010.05.04
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to a compound of formula (i) where a is a ring aromatic or non aromatic hydrocarbon c5-c6 and optionally one or more carbon Atoms are replaced by a group X l is a Union simple, NH d is o, S, SO2, NR4, CH2 Z1 and Z2 are each one, S, NR5, R1 is H, halogen, haloalca Nile, haloalquenilo, among others R2 is H, NH2, Oh, among others R3 is H, alcanilo, alquenilo,Alquinilo, among others, cycloalkyl, aryl, heteroaryl R4 is H, cycloalkyl, among others R5 is H, ho, alcaniloxi, alqueniloxi or aryl -, alcanilo, among others R8 is H, alcanillo, alquenilo or alquinilo X is s or n, NR4, SO2, so and is H, halogen, haloalcanilo, haloalcaniloxi, among others and S alquenilo, aryl, heteroaryl,Alquinilo or FUSED bicyclic or tricyclic Ring System m, N, Q and R are each 0 - 1 t is 0-3.un Preferred Compound is acid, 3 - (2,3,5,6 - tetrafluoro - 3 - Diphenyl - 4 - (trifluoromethoxy ilcarbamoil) - thiophene-3 - carboxylic acid. In addition to such a Pharmaceutical composition.This Compound is a dihidroorato dehydrogenase inhibitor used for the treatment and Prevention of Viral DiseasesSE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: A ES UN ANILLO HIDROCARBONADO AROMATICO O NO AROMATICO C5-C6 DONDE OPCIONALMENTE UNO O MAS ATOMOS DE CARBONO SE REEMPLAZAN POR UN GRUPO X L ES UNA UNION SIMPLE, NH D ES O, S, SO2, NR4, CH2 Z1 Y Z2 SON CADA UNO O, S, NR5 R1 ES H, HALOGENO, HALOALCANILO, HALOALQUENILO, ENTRE OTROS R2 ES H, NH2, OH, ENTRE OTROS R3 ES H, ALCANILO, ALQUENILO, ALQUINILO, CICLOALQUILO, ENTRE OTROS R4 ES H, ARILO, HETEROARILO, CICLOALQUILO, ENTRE OTROS R5 ES H, HO, ALCANILOXI, ALQUENILOXI, O-ARILO, ALCANILO, ENTRE OTROS R8 ES H, ALCANILLO, ALQUENILO O ALQUINILO X ES S, O, N, NR4, SO2, SO Y ES H, HALOGENO, HALOALCANILO, HALOALCANILOXI, ENTRE OTROS E ES ARILO, HETEROARILO, ALQUENILO, ALQUINILO O UN SISTEMA DE ANILLOS FUSIONADOS BICICLICO O TRICICLICO m, n, q Y r SON CADA 0-1 t ES 0-3.UN COMPUESTO PREFERIDO ES ACIDO 3-(2,3,5,6-TETRAFLUORO-3-TRIFLUOROMETOXI-BIFENIL-4-ILCARBAMOIL)-TIOFE
