A DNA TARGET SEQUENCE OF A XERODERMA PIGMENTOSUM GENE SPARKING MEGANUCLEASE VARIANTS AND THEIR USE

• 收藏
• 分享

专利权人:

CELLECTIS

发明人:

ARNOULD, SYLVAIN,PEREZ-MICHAUT, CHRISTOPHE,SMITH, JULIANNE

申请号：

AT07734243

公开号：

AT553192T

申请日:

2007.02.13

申请国别(地区):

AT

年份:

2012

代理人:

摘要：

An I-CreI variant which has at least two substitutions, one in each of the two functional subdomains of the LAGLIDADG (SEQ ID NO: 229) core domain situated from positions 26 to 40 and 44 to 77 of I-CreI, said variant being able to cleave a DNA target sequence from a xeroderma pigmentosum gene. Use of said variant and derived products for the prevention and the treatment of Xeroderma pigmentosum.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/