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A DNA TARGET SEQUENCE OF A XERODERMA PIGMENTOSUM GENE SPARKING MEGANUCLEASE VARIANTS AND THEIR USE
专利权人:
CELLECTIS
发明人:
ARNOULD, SYLVAIN,PEREZ-MICHAUT, CHRISTOPHE,SMITH, JULIANNE
申请号:
AT07734243
公开号:
AT553192T
申请日:
2007.02.13
申请国别(地区):
AT
年份:
2012
代理人:
摘要:
An I-CreI variant which has at least two substitutions, one in each of the two functional subdomains of the LAGLIDADG (SEQ ID NO: 229) core domain situated from positions 26 to 40 and 44 to 77 of I-CreI, said variant being able to cleave a DNA target sequence from a xeroderma pigmentosum gene. Use of said variant and derived products for the prevention and the treatment of Xeroderma pigmentosum.
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