Andrew Tai-Ann Cheng,Yuan-Tsong Chen,Chien-Hsiun Chen,Chau-Shoun Lee,Ming Ta Michael Lee
申请号：
US14764448
公开号：
US09797015B2
申请日:
2014.01.29
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Described herein is a method of determining lithium responsiveness in a bipolar disorder patient. The method includes obtaining a sample from a patient having bipolar disorder, and assaying the sample for the presence or absence of one or more glutamate decarboxylase-like 1 (GADL1) gene variants selected from the group consisting of a T allele of the single nucleotide polymorphism (SNP) rs17026688, a G allele of the SNP rs17026651, and GADL1 1VS8+48delG. The presence of one or more of the GADL1 gene variants indicates that the patient is responsive to lithium treatment.
