KUMAR, VIKRAM S.,HESSON, DAVID P.,HUANG, PING,JIA, MO,YOU, XIANJUN
申请号：
CA3094324
公开号：
CA3094324A1
申请日:
2019.03.26
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2'-halo-1-1'-biphenyl-4-yl)- quinoline carboxylic acids, which are useful as DHODH inhibitors.
