The present invention relates to compounds which are useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases. Disclosed herein are new compounds and compounds based on pyrazolopyrazines and their application as pharmaceuticals for the treatment of disease.本發明係關於適用作用於治療或預防癌症及其他PTP介導疾病之PTPN11抑制劑的化合物。本文所揭示者是新穎化合物及基於吡唑并吡嗪之化合物及其等作為藥品用於治療疾病之應用。