It possesses CaSR agonisuto activity, many variation chemical compounds are searched, particular chemical compound is contained, the CaSR agonisuto medicine, the medicine composition, offer the preventive of the diarrhea or remedy medicine and the body taste grant medicine. The glutamic acid derivative which possesses CaSR agonisuto activity or that the CaSR agonisuto medicine which features that the salt which it can allow medicine is contained, the medicine composition, the preventive of the diarrhea or remedy medicine and the body taste grant medicine.CaSRアゴニスト活性を有する多くのバリエーション化合物を探索し、当該化合物を含有する、CaSRアゴニスト剤、医薬組成物、下痢の予防若しくは治療剤及びコク味付与剤を提供すること。CaSRアゴニスト活性を有するグルタミン酸誘導体又はその医薬的に許容しうる塩を含有することを特徴とするCaSRアゴニスト剤、医薬組成物、下痢の予防若しくは治療剤及びコク味付与剤。
