OPTICALLY ACTIVE DIBENZYLAMINE DERIVATIVE, AND MANUFACTURING METHOD FOR SAME

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专利权人:

LTD.;코와 가부시키가이샤;KOWA COMPANY, LTD.;KOWA COMPANY

发明人:

OHGIYA TADAAKI,오기야, 다다아키,MURAKAMI TAKESHI,무라카미, 다케시,MIYOSAWA KATSUTOSHI,미요사와, 가츠토시,SHIBUYA KIMIYUKI,시부야, 기미유키,YAMAZAKI KOICHI,야마자키, 고이치,KUSAKABE TAICHI,구사카베, 다이치

申请号：

KR1020137000104

公开号：

KR1020130111512A

申请日:

2011.06.03

申请国别(地区):

KR

年份:

2013

代理人:

摘要：

Substantially optically pure (S)-trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid, or a salt thereof, or a solvate thereof, which has actions of reducing amount of PCSK9 protein and increasing amount of LDL receptor.PCSK9 단백량을 저하시켜 LDL 수용체량을 증가시키는 작용을 갖는 실질적으로 광학적으로 순수한 (S)-트랜스-{4-[({2-[({1-[3,5-비스(트리플루오로메틸)페닐]에틸}{5-[2-(메틸술포닐)에톡시]피리미딘-2-일}아미노)메틸]-4-(트리플루오로메틸)페닐}(에틸)아미노)메틸]시클로헥실}아세트산 또는 그의 염, 또는 그들의 용매화물.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/