The invention relates to a method for preparing hollow particles, including: 1) spray-depositing, in particular in a fluidized air bed and onto a substrate that is partially soluble in a liquid medium M, a coating containing: 40 to 100 wt % of at least one compound that is insoluble in water having a pH of less than 5 and that comprises at least one polymer； and 60 to 0 % of at least one water-soluble compound； 2) extracting a portion of the substrate in the medium M； and 3) drying the particles obtained in step 2. The invention also relates to the resulting hollow particles and to the uses thereof, in particular in floating pharmaceutical compositions.
