George D. Yancopoulos;Scott Mellis;Margaret Karow;Joanne Papadopoulos
发明人:
Scott Mellis,Margaret Karow,George D. Yancopoulos,Joanne Papadopoulos
申请号：
US13224372
公开号：
US08414876B2
申请日:
2011.09.02
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Methods of treating, inhibiting, or ameliorating an autoinflammatory disorder, disease, or condition in a subject in need thereof, comprising administering to a subject in need a therapeutic amount of an interleukin 1 (IL-1) antagonist, wherein the autoinflammatory disorder, disease, or condition is treated, inhibited, or ameliorated. The IL-1 antagonist is a molecule capable of binding and inhibiting IL-1. The therapeutic methods are useful for treating a human adult or child suffering from Neonatal Onset Multisystem Inflammatory Disorder (NOMID/CINCA), Muckle-Wells Syndrome (MWS), Familial Cold Autoinflammatory Syndrome (FCAS), familial mediterranean fever (FMF), tumor necrosis factor receptor-associated periodic fever syndrome (TRAPS), or systemic onset juvenile idiopathic arthritis (Still's Disease).
