AIHUA WANG,ANNE FOURIE,CRAIG R. WOODS,DAVID A. KUMMER,HARIHARAN VENKATESAN,JAMES P. EDWARDS,JOAN PIERCE,KENT BARBAY,KEVIN D. KREUTTER,KRISTI A. LEONARD,MAUD URBANSKI,RACHEL NISHIMURA,RONALD L. WOLIN,S
申请号：
BR112015008308
公开号：
BR112015008308A2
申请日:
2013.10.15
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract the present invention comprises compounds of formula i. wherein i: r1, r2, r3, r4, r5, r6, r7, r8, and r9 are defined in the specification. the invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. the invention also comprises a method of modulating ror? t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim "The present invention relates to compounds of formula (I). wherein: r1, r2, r3, r4, r5, r6, r7, r8 and r9 are defined in the descriptive report. The invention also comprises a method for treating or alleviating a syndrome, disorder or disease, said syndrome, disorder or disease being rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ror? t activity in a mammal by administering a therapeutically effective amount of at least one compound as defined in claim 1.abstract the present invention comprises compounds of formula i. formula i wherein: r1, r2, r3, r4, r5, r6, r7, r8, and r9 are defined in the specification. the invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. the invention also comprises a method of modulating ror?t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1. tradução do resumo resumo patente de invenção "moduladores de quinolinila ligados por metileno do ror-gama-t" a presente invenção refere-se a compostos de fórmula (i). fórmula i em que: r1, r2, r3, r4, r5, r6, r7, r8 e r9 são definidos no relatório descritivo. a invenção compreende também um método para tratamento ou alívio de uma síndrome, distúrbio ou doença, sendo que a dita síndrome, distúrbio ou doença é artrite reumatoide ou psoríase. a invenção compreende, também, um método de mod
