Indiana University Research and Technology Corporation
发明人:
Mark R. Kelley, III,Travis Jerde,Melissa L. Fishel
申请号：
US16479987
公开号：
US20190365689A1
申请日:
2018.01.25
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Methods of using redox APE1/Ref-1 inhibitors to treat prostate cancer, and particularly, metastatic prostate cancer, are disclosed. Particularly, small molecule inhibitors of APE1/Ref-1 redox activity have been found to decrease cell proliferation and induce cell cycle arrest in metastatic prostate cancer cell lines. Further, these APE1/Ref-1 redox inhibitors can be used to reduce expression of survivin, which has been shown to be overexpressed in primary and metastatic tumors.
