A substance delivery device for use with a container or container holder containing the substance, the device comprising a body (113) arranged to house or hold the container or container holder, means (200) for priming the container or container holder, the priming means (200) comprising a movable portion which is arranged to be moved during the priming operation, and means for impeding or preventing a further operation from being carried out before the priming operation has been carried out, wherein the further operation comprises delivery of the substance and/or adjustment of the dose of the substance to be delivered.
