compound, pharmaceutical composition, methods of treating an individual for a proliferative disorder of inducing cancer cell apoptosis, and of inhibiting kinase activity in a mammal, and, compound preparation process
TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OFHIGHER EDUCATION
发明人:
E. PREMKUMAR REDDY,M. V. RAMANA REDDY
申请号：
BR112013002375
公开号：
BR112013002375A2
申请日:
2011.07.21
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
compound, pharmaceutical composition, methods of treating an individual for a proliferative disorder of inducing cancer cell apoptosis, and of inhibiting kinase activity in a mammal； and, compound preparation process. The compounds according to formula (I) as well as salts thereof: wherein R2 and R2 are as defined herein, are useful as antiproliferative agents and kinase inhibitors. Synthetic methods for preparing the compounds of formula (I) are also provided.composto, composição farmacêutica, métodos de tratar um indivíduo para um distúrbio proliferativo de induzir a apoptose das células cancerígenas, e de inibir a atividade de cinase em um mamífero, e, processo de preparação de composto. os compostos de acordo com a fórmula (i) bem como sais destes: em que r^ 1^ e r^ 2^ são como definidos neste, são úteis como agentes antiproliferativos e inibidores de cinase. os métodos sintéticos para a preparação dos compostos da fórmula (i) também são fornecidos.
