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7-azaindole derivatives as selective type-11-beta-hydroxysteroid dehydrogenase inhibitors
专利权人:
Merck Patent Gesellschaft Mit Beschränkter Haftung
发明人:
Denis Carniato,Didier Roche,Melanie Schultz,Sophie Hallakou-Bozec
申请号:
BRPI0819219
公开号:
BRPI0819219A2
申请日:
2008.10.01
申请国别(地区):
BR
年份:
2020
代理人:
摘要:
7-azaindole derivatives as selective type-11-beta-hydroxysteroid dehydrogenase inhibitors the present invention relates to 7-azaindole derivatives of formula (i) as selective inhibitors of the type 11-beta-hydroxysteroid dehydrogenase (11beta- hsd-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions .derivados de 7-azaindol como inibidores de 11-beta-hidroxiesteroide desidrogenase tipo 1 seletivos a presente invenção refere-se a derivados de 7-azaindol da fórmula (i) como inibidores seletivos da enzima 11-beta-hidroxiesteroide desidrogenase tipo 1 (11beta-hsd-1) e o uso de tais compostos para o tratamento e prevenção de síndrome metabólica, diabetes, resistência à insulina, obesidade, distúrbios lipídicos, glaucoma, osteoporose, distúrbios cognitivos, ansiedade, depressão, distúrbios imunes, hipertensão e outras doenças e condições.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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