The present invention relates to system for extracting physiological information indicative of at least one vital sign of a subject from detected light transmitted through a part of the subject (1). To overcome the limitations of the contactless camera-based reflective PPG technique and classical contact sensors the proposed system comprises a medical instrument (12, 24) for at least partly introduction into a subjects body, one or more light sources (14, 15) for emitting light, said one or more light sources being mounted to the part of the medical instrument that is introduced into the subjects body during use, a light detection unit (16) for detecting light emitted by said one or more light sources and transmitted through a part of the subject, and a processing unit (18) for deriving physiological information indicative of at least one vital sign from the detected light using remote photo-plethysmography. Said light detection unit (16) comprises an imaging unit, in particular a camera, for acquiring a sequence of images of skin areas of the subject over time. Said processing unit (18) is configured for deriving physiological information indicative of at least one vital sign from said sequence of images using remote photo-plethysmography.
