An intraorally administrable vaccine compositionuseful to be a preventive or therapeutic agent forinfectious diseases, and effectively induces a systemicimmune response or a mucosal immune response is provided.A vaccine composition for administration to the oral cavityof a human or an animal, the vaccine composition containingat least one antigen derived from an infectious disease,and at least one selected from the group consisting of atoll-like receptor 4 (TLR4) agonist, a toll-like receptor2/6 (TLR2/6) agonist, and cyclic dinucleotide, or aderivative or salt thereof.
