PROBLEM TO BE SOLVED: To provide a pharmaceutical composition which includes, as an active ingredient, a novel low molecular weight compound for inhibiting production of derivative type MMPs, particularly the production of MMP-9, rather than production of constancy type MMP-2, and which is useful as a preventive/therapeutic agent for an autoimmune disease, an inflammatory bowel disease or osteoarthritis.SOLUTION: This pharmaceutical composition includes an amide derivative expressed by formula (I), or its pharmacologically acceptable salt as an active ingredient.COPYRIGHT: (C)2013,JPO&INPIT【課題】恒常型のMMP-2の産生よりも誘導型のMMPs、特にMMP-9の産生を抑制する新規な低分子化合物を有効成分として含有し、自己免疫疾患、炎症性腸疾患又は変形性関節症の予防薬/治療薬として有用な医薬組成物を提供する。【解決手段】下記式(I)(式中の各記号は明細書中で定義した通りである。)で示されるアミド誘導体又はその薬理学的に許容される塩を有効成分として含有する医薬組成物。【選択図】なし
