Patrick Brossard;Michael Scherz;Oliver Nayler;Jasper Dingemanse;Beat Steiner
发明人:
Patrick Brossard,Jasper Dingemanse,Oliver Nayler,Michael Scherz,Beat Steiner
申请号：
US12922777
公开号：
US08785484B2
申请日:
2009.03.12
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to a dosing regimen for a selective S1P1 receptor agonist, whereby the selective S1P1 receptor agonist is administered to a subject in such a way that during the initial treatment phase the selective S1P1 receptor agonist is administered at a dose which induces desensitization of the heart wherein said dose is below the target dose, and at a dosing frequency that sustains desensitization of the heart, until no further acute heart rate reduction occurs, followed by dose up-titration to the target dose of the selective S1P1 receptor agonist.
