Presented are systems and methods for examining patients and generating diagnostic medical data to make automated diagnoses and treatment recommendations to patients and doctors. Various embodiments of the present invention provide patients with diagnostic tools and audio/video guidance to reliably and accurately perform clinical grade diagnostic measurements of key vital signs. In embodiments, this is accomplished by using an automated remote (or local, e.g., in the form of a kiosk) end-to-end medical diagnostic system that monitors equipment usage for accuracy. The diagnostic system analyzes patient responses, measurement data, and patient-related information to generate diagnostic and/or treatment information that may be shared with healthcare professionals and specialists, as needed. Automation provides for timely, hassle-free, and cost-effective health care management that takes the stress out of doctor visits, while delivering personalized health care. The high accuracy of generated diagnostic data improves health care to patients and reduces the risk of medical malpractice for treating physicians.