A hemostasis valve (34) includes a valve body having a proximal port, a distal port and a lumen extending between the proximal port and distal port. A valve is located in the lumen adjacent the proximal port. A rotating luer connector (48) is rotatably connected to the valve body proximate the distal port to secure a guide catheter (122). The rotating luer connector includes a driven member (56) configured to be rotatably driven by a drive mechanism (36).
