The present invention relates to the field of washing devices, and relates in particular to a hand-held clothes washing device, comprising: a housing and an ultrasonic generating device which is disposed within the housing; the housing comprises a flat bottom wall, while the ultrasonic generating device is provided with a plurality of ultrasonic vibration ends; the ultrasonic vibration ends are distributed on the bottom wall, and the ultrasonic vibration ends contact clothes to be washed during washing. The beneficial effects of the present invention are as follows: by means of configuring the flat bottom wall and disposing the plurality of ultrasonic vibration ends on the bottom wall, the configuration of the plurality of ultrasonic vibration ends causes the washing area to increase, while placement of the hand-held clothes washing device is convenient; a user may place the hand-held clothes washing device on the clothes to be washed to carry out washing without having to continuously hold the device, reduci