An assembly structured to secure a catheter, such as an IV tube to a predetermined portion of a patients body such that the IV tube is anchored adjacent an entry site. A base is structured and configured to engage the predetermined body portion and includes an opening for exposure of and access to the entry site. A support member is selectively positionable at variable locations relative to the opening in adjacent relation to the entry site such that the IV tube is mounted on an exterior or exposed portion of the support member so as to access the entry site through the opening and eliminate any type of adhesive strip or like connector contacting or being secured to the patients skin.