INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);UNIVERSITE PARIS DIDEROT PARIS 7;ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
发明人:
JAULIAC, SEBASTIEN,CAMARGO, LIVIA
申请号：
CA3019412
公开号：
CA3019412A1
申请日:
2017.03.29
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention relates to a composition comprising secreted extracellular vesicles (SEV) of cells expressing nuclear factor of activated T-cells, cytoplasmic, calcineurin- dependent 4(NFATC4), for use in the treatment of cancer or in the treatment or prevention of metastatic cancer. It further relates to in vitromethods for determining or predicting the therapeutic efficiency of a treatment with a composition comprising SEV of cells expressing NFATC4 in a cancer patient, based on the ability of the composition comprising SEV of cells expressing NFATC4 to induce an increase in TGFß1 expression level.
