JAMES G. GREGER JR.,JOEL DAVID GRESHOCK,KURT R. AUGER,KURTIS EARL BACHMAN,LI LIU,SHANNON RENAE MORRIS,SYLVIE LAQUERRE,TONA M. GILMER
申请号：
BR112012006968
公开号：
BR112012006968A2
申请日:
2010.09.28
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
The present invention relates to a method of treating cancer in a mammal and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a novel combination comprising the MEK inhibitor: N-{3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and the PI3 kinase inhibitor: 2,4-difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same, and methods of using such combinations in the treatment of cancer.
