A polypeptide and polynucleotides encoding same comprising at least two carboxy-terminal peptide (CTP) sequences of chorionic gonadotropin attached to a peptide-of-interest are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.Mevcut buluş koryonik gonadotropinin bir amino terminal karboksi-terminal peptidini (CTP) ve buna bağlı iki karboksi-terminal koryonik gonadotropin CTP'yi içeren bir büyüme hormonu proteininin tıbbi kullanımıyla ilgilidir.