This invention is to provide a transdermal permeation preparation which includes a concentrated transdermal active ingredient laminate and exhibits high transdermal permeation effect； and a method for producing the preparation A transdermal permeation preparation which comprises a base material which is a hydrophilic macromolecule which can swell after absorbing the water and/or water-containing alcohol and comprises a transdermal active ingredient which is in a molecular weight higher than 1000 Dalton and can dissolve or suspend in water and/or water-containing alcohol laminated on the surface of the base material, ； and a method for producing the transdermal permeation preparation wherein the transdermal active ingredient of a molecular weigh higher than 1000 Dalton is dissolved or suspended in water and/or water-containing alcohol to form an aqueous solution or suspension and the said aqueous solution or suspension is coated on the surface of base materials which are hydrophilic macromolecules which can swell after absorbing the water or e water-containing alcohol as a result of absorption of the water or the water-containing alcohol in the base material, thereby forming a layer containing the transdermal active ingredient in a concentrated state on the surface of the base material.
