MEDIA MILLING PROCESS FOR THE MANUFACTURE OF ACTIVE PHARMACEUTICAL INGREDIENTS IN PROPELLANTS

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专利权人:

Merck Sharp & Dohme Corp.

发明人:

BHARATWAJ, Balaji,CHAMARTHY, Sai Prasanth,OREKIE, Chinedu, G.,SON, Yoen-Ju

申请号：

EP14872578

公开号：

EP3082708A4

申请日:

2014.12.12

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The invention disclosed herein is a novel media milling process performed in an atmosphere of propellants(s) utilizing a resonant acoustic mixing (RAM) device. The process is utilized to reduce the particle size of API (optionally including excipients) to a respirable size range while ensuring the retention of the crystallinity of the milled API.

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中国工程科技知识中心

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http://www.ckcest.cn/home/