2. Method of obtaining the compound and using the compound as the opposite cube of MDM2 Claim 1: a compound according to formula (1), wherein X is selected from h, F, Cl, Br, I, cyanogen, nitrate, Ethiopia, cyclopropene, methyl, ethyl, isopropyl, ethylene and methoxy groups, and is one to four groups independently selected from h, F, Cl, Br, I, CN, oh, nitro and low tar groups. Cycloquilo, Alcoy subject, Alcoy subject, cycloquilo subject, cyclo cyclo quenilo and subjective poly； Z is Alcoy subject； R1 selects the group composed of the following asphalt, the lower alternative asphalt, the lower alternative alquenilo, and the lower alternative alquenilo,a. Arilo, arilo substitutes, heteromorphic substitutes, heterocyclic substitutes, cyclopropene, cyclopropene substitutes, cyclopropene substitutes and cyclopropene substitutes； R 2 is the alternative phenyl (2) selected from the residue of formula group；W es-f, - Cl o-br； V es-h o-f； R3 were selected from the following groups: low AlOx, low AlOx substitute, rental, diaklamino, gluconic acid, hexosas, carbamate, pyridinic acid, carbamate, carbamate, natural and unnatural amino acids, - oc8322； (o) n (ch832323) 8322；-(och 8322； ch83222) - 8345； - Oh, - (och8322； (ch8322) - 8345； - och 832323；- (OCH CH) -OP (O) (OR)-OCH -C (O) - (OCH CH) -OH -OCH C (O) - (OCH CH) -OCH-NH (CH -CH O) -CH-NH (CH CH O) -H -OCH C (O) NH (CH CH O) -CH-O-R83099,-OCH₂-R⁵,OCH₂CH₂-R⁵,-OCH C (O) -R-NH (och 8322； ch8322)； - nh8322y-och8322； - ch832222-amino acid, n is 3-80； r8308s is hydrogen or benzene； rc83099 is composed of heterocycle, heterocycle substitution, diallamine, rental and aminomethanol； or select a salt or a pharmaceutically acceptable ester；Métodos para la obtención de los compuestos así como el uso de tales compuestos como antagonistas de MDM2. Reivindicación 1: Un compuesto de la fórmula (1) en la que: X se elige entre el grupo formado por H, F, Cl, Br, I, ciano, nitro, etinilo, ciclopropilo, metilo, etilo, isopropilo, vinilo y met
