THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;Brian B. AVANTS
发明人:
Benjamin M. Jackson,Robert C. Gorman,Joseph H. Gorman,Alison M. Pouch,Chandra M. Sehgal,Paul A. Yushkevich,Brian B. Avants,Hongzhi Wang
申请号：
US14774325
公开号：
US20160035087A1
申请日:
2014.03.12
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A method is provided for measuring or estimating stress distributions on heart valve leaflets by obtaining three-dimensional images of the heart valve leaflets, segmenting the heart valve leaflets in the three-dimensional images by capturing locally varying thicknesses of the heart valve leaflets in three-dimensional image data to generate an image-derived patient-specific model of the heart valve leaflets, and applying the image-derived patient-specific model of the heart valve leaflets to a finite element analysis (FEA) algorithm to estimate stresses on the heart valve leaflets. The images of the heart valve leaflets may be obtained using real-time 3D transesophageal echocardiography (rt-3DTEE). Volumetric images of the mitral valve at mid-systole may be analyzed by user-initialized segmentation and 3D deformable modeling with continuous medial representation to obtain, a compact representation of shape. The regional leaflet stress distributions may be predicted in normal and diseased (regurgitant) mitral valves using the techniques of the invention.
