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METHOD FOR PRODUCING A DERMATOLOGICAL COMPOSITION CONTAINING AN OLEOSOMA
专利权人:
ГАЛДЕРМА РЕСЕРЧ ЭНД ДЕВЕЛОПМЕНТ (FR)
发明人:
ДЖЕДУР Амель Сафья (FR)
申请号:
RU2014152996
公开号:
RU2014152996A
申请日:
2013.05.30
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A method of producing an oil-in-water emulsion formed by liquid globules, each provided with a liquid crystal lamellar shell and dispersed in the aqueous phase, each oil globule being uniformly coated with a monolamellar or oligolamellar layer obtained from at least one lipophilic surface active substance, at least one hydrophilic surfactant and at least one specific anionic surfactant, The method comprises the following steps: a) mixing at a temperature of not more than 75 ° C of a lipophilic surfactant, a hydrophilic surfactant, a specific anionic surfactant and all ingredients of liquid globules to obtain a homogeneous mixture of the oil phase (A); b ) mixing at a temperature of not more than 75 ° C all the ingredients of the aqueous phase to obtain a homogeneous mixture of the aqueous phase (B); c) adding the aqueous phase (B) obtained in stage b) to the oil phase (A) obtained in stage a) , with strength stirring to obtain a homogeneous emulsion; d) cooling the homogeneous emulsion obtained in step c) with slow stirring until the emulsion reaches a temperature of less than or equal to 50 ° C; moreover, the method differs in that the number of stages is less than or equal to 5; high pressure homogenizer, the method does not have a preliminary emulsification stage, and any stage of the method is carried out at a temperature less than or equal to 75 ° C. 2. A method according to claim 1, characterized in that the lipophilic surfactant has an HLB value in the range of1. Способ получения эмульсии типа "масло в воде", образованной жидкими глобулами, каждая из которых снабжена жидкокристаллической ламеллярной оболочкой и которые диспергированы в водной фазе, причем каждая масляная глобула единообразно покрыта моноламеллярным или олиголамеллярным слоем, полученным из по меньшей мере одного липофильного поверхностно-активного вещества, по меньшей мере одного гидрофильного поверхностно-активного вещества и по меньшей мере одного определенного анионогенного поверхностно
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