Embodiments of a method, a system, and a non-transitory computer readable medium for use in interactive magnetic resonance imaging are presented. An initial region of interest of a subject is scanned to acquire imaging data using an initial imaging protocol. Anatomical labeling information corresponding to a plurality of regions corresponding to the subject may be determined based on the acquired data and/or previously available information. Particularly, determining the anatomical labeling information may include identifying one or more features of interest corresponding to the initial region of interest. Further, input from an operator corresponding to a desired imaging task may be received interactively. The imaging protocol may be updated in real-time by selectively configuring one or more imaging parameters that optimize implementation of the desired imaging task based on the determined anatomical labeling information. A subsequent scan may be performed using the updated imaging protocol for completing the desired imaging task.