IAKOVLEV, Pavel Andreevich,GAVRILOV, ALEKSEY SERGEEVICH,ALESHUNIN, Pavel Aleksandrovich,GORBUNOVA, Svetlana Leonidovna,REKHARSKY, Mikhail Vladimirovich,KOZHEMYAKINA, Natalia Vladimirovna,KUKUSHKINA, A
申请号：
MA45888
公开号：
MA45888A1
申请日:
2017.11.16
申请国别(地区):
MA
年份:
2020
代理人:
摘要：
The present invention relates to a new compound of formula I, or a pharmaceutically acceptable salt, solvent or stereoisomer thereof, wherein V1 is C or N, V2 is C ((R2) or n), therefore, if V1 is C, V2 is n, if V1 is C, V2 is C ((R2),,Or if V1 is n, V2 is C ("R2")；Each n, K is an independent 0, 1； each R2, R11 is an independent h, D, Hal, CN, Nrc（）1. Alkoxy C1-C6； R3 is h, D, hydroxyl, c() alkyl, c() C1-C6, c() alkyl,The alkenyl group is C () C2-C6, the alkyl group is C1-C6； R4 is h, Hal, CN, conr'sA hydroxyl group, a C1-C6 alkyl group, a C1-C6 alkyl group, a C1-C6 alkyl group, a C2, NH, O or chemical bond； R1 is selected from the fragment group, including: fragment 1, segment 2, fragment 3, each A1, A2, A3, A4 independent of CH, N, chal； every A5, A6, a7, A8, A9 is independent of C, ch or N； R5 is h, CN, Hal, conrA C1-C6 alkyl group that is not substituted or substituted by one or more halogens； each R and R "is independently selected from the group containing the following substances: H, a C1-C6 alkyl group, a C1-C6 cycloalkyl group, an aryl group, a R6, selected from the group: [(formula II)] each R7, R8, R9, R10 is independent of vinyl, a methylacetylene； Hal C, Br, I, f with the characteristics of brugton tyrosine kinase inhibitorsThe invention also relates to a pharmaceutical composition containing the compound and its use as a drug for treating diseases and disorders.La présente invention concerne un nouveau composé représenté par la formule i, ou un sel, un solvate ou un stéréoisomère pharmaceutiquement acceptable de celui-ci, dans laquelle : v1 est c ou n, v2 est c(r2) ou n, ainsi si v1 est c alors v2 est n, si v1 est c alors v2 est c(r2), ou si v1 est n alors v2 est c(r2)； chaque n, k est indépendamment 0, 1； chaque r2, r11 est indépendamment h, d, hal, cn, nr'r", c(o)nr'r", un alkoxy c1-c6； r3 est h, d, un hydroxy, un alkyle en c(o)c1-c6, un alcényle en c(o)c2-c6 , un alcényle en c(o)c2-c6, un alkyle en c1-c6； r4 est h, hal, cn, conr'r", un hydroxy, un a
