As for several execution features of this invention, micro RNA (as for this, micro RNA 124 and micro RNA 137 and/or micro RNA 9* is included, but either in vitro or in vivo in the neuron differentiation of the versatile characteristic stroma cell it is not limited in these), via the application of the revelation product of these micro RNA, or the molecule or the composition which include the functional element of these micro RNA the method of inducing selectively, the system and the composition are included. In addition, as for several execution features of this invention, the damage and the disease of the mammal (as for these, the damage or the disease of the nervous system which can cause the cell or system function which is decreased is included, but remedy dosage and use of the cell which it is not limited) in order to remedy catches in these and was induced are included.< Selective figure >It is not本発明のいくつかの実施態様は、マイクロRNA(これは、マイクロRNA-124、マイクロRNA-137及び/又はマイクロRNA-9*を含むが、これらに限定されない)、これらのマイクロRNAの発現産物、及びこれらのマイクロRNAの機能的要素を含む分子及び組成物の適用を通じて多能性ストローマ細胞のニューロン分化をインビトロ又はインビボのいずれにおいても選択的に誘導する方法、システム及び組成物を含む。また、本発明のいくつかの実施態様は、哺乳動物の損傷及び疾患(これらは、減少された細胞又はシステム機能を生じうる神経系の損傷又は疾患を含むが、これらに限定されない)を治療するためのかかる誘導された細胞の治療的投与及び使用を含む。【選択図】なし
