INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT onion °nolo OH 1101 H Oil 0II En oimIE (10) International Publication Number WO 2018/182512 Al (51) International Patent Classification: A23L 33/135 (2016.01) C12C 11/00 (2006.01) C12C 12/00 (2006.01) (21) International Application Number: PCT/SG2018/050139 (22) International Filing Date: 27 March 2018 (27.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201702468S 27 March 2017 (27.03.2017) SG (71) Applicant: NATIONAL UNIVERSITY OF SINGA- PORE [SG/SG]； 21 Lower Kent Ridge Road, Singapore 119077 (SG). (72) Inventors: LIU, Shao Quan； c/o National University of Singapore, Faculty of Science, Department of Chemistry, 21 Lower Kent Ridge Road, Singapore 119077 (SG). CHAN, Mei Zhi, Alcine； c/o National University of Singapore, Fac- ulty of Science, Department of Chemistry, 21 Lower Kent Ridge Road, Singapore 119077 (SG). (74) Agent: PATEL, Upasana； Marks & Clerk Singapore LLP, Tanjong Pagar, P.O. Box 636, Singapore 910816 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG,
