An object of the present invention is to provide a disintegrative particulate composition that can be used for an orally disintegrating tablet having both excellent tablet hardness and disintegrability. This invention relates to a method for the production of a disintegrative particulate composition including three components consisting of a first disintegrator component having sedimentation volume in water of 4.0 cm3/g or more, a second disintegrator component other than the first disintegrator component and an excipient, which comprises a first wet granulation step using any two of the three components and a second wet granulation step using the granules obtained in the first wet granulation step and at least the remaining one component not used in the first wet granulation step the disintegrative particulate composition thus produced and an orally disintegrating tablet comprising a medicinal ingredient and the disintegrative particulate composition.本發明提供一種可用於具有優異之錠劑硬度及崩解性之口腔內崩解錠劑之崩解性粒子組成物及其製造方法等。本發明係關於一種崩解性粒子組成物之製造方法、該所製造之崩解性粒子組成物、及含有該崩解性粒子組成物及藥效成分之口腔內崩解錠劑等,上述崩解性粒子組成物之製造方法係製造含有第一崩解劑成分、第一崩解劑以外之第二崩解劑成分及賦形劑此三種成分之崩解性粒子組成物的方法,上述第一崩解劑成分係由在水中之沈澱體積為4.0cm3/g以上之崩解劑所構成,此崩解性粒子組成物之製造方法之特徵在於包含:第一濕式造粒步驟,其係使用該三種成分中之任意兩種成分;及第二濕式造粒步驟,其係至少使用第一濕式造粒步驟中所獲得之造粒物與該三種成分中之於第一濕式造粒步驟中未使用之剩餘之一成分。
