A multilayer scaffold device that includes a luminal electrospun layer, the luminal electrospun layer configured to provide a suitable environment to induce epithelium formation on the scaffold, an exterior electrospun layer, the exterior electrospun layer located radially exterior to the luminal electrospun layer, the exterior electrospun layer configured to induce formation of non-epithelial tissue； and at least one intermediate layer interposed between the luminal electrospun layer and that exterior electrospun layer, the intermediate layer configured to organize the formation of the respective epithelial tissue and the non-epithelial tissue.
