PROBLEM TO BE SOLVED BY THE INVENTION The present invention aims to clarify the possibility of development as a health food by elucidating whether the effect of preventing the thrombosis is present at the end of the rice bran black vinegar and the rice vermicelli mushrooms .SOLUTION: The inventors of the present invention focused on elevation of PAI-1 due to inflammatory stimulation, and found that inhibition of blood PAI-1 elevation by inflammatory stimulation, inhibition of PAI-1 production from vascular endothelial cells under inflammatory stimulation As a result of keen examination on the possibility of the thrombus preventive effect of black vinegar using suppression as an index, it was found for the first time in the world that this action is present in black vinegar, and the present invention was completed.BACKGROUND OF THE INVENTION【課題】本発明は、米黒酢および米黒酢もろみ末に血栓症を予防する効果が存在するかを科学的に解明し、健康食品として開発できる可能性を明らかにすることを課題とする。【解決手段】本発明者らは、炎症性刺激によるPAI-1の上昇に注目し、炎症性刺激による血中PAI-1上昇の抑制、炎症性刺激下の血管内皮細胞からのPAI-1産生抑制を指標に、黒酢の血栓予防効果の可能性について鋭意検討を行ったところ、黒酢に当該作用があることを世界で初めて見出し、本発明を完成した。【選択図】図1
