COMPOSITIONS À LIBÉRATION CONTRÔLÉE COMPRENANT UNE COMBINAISON DE DINITRATE D'ISOSORBIDE ET DE CHLORHYDRATE D HYDRALAZINE

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专利权人:

ELAN PHARMA INTERNATIONAL LIMITED

发明人:

REKHI, GURVINDER,HAMM, SHARON,SIDWELL, RICHARD

申请号：

EP06826636

公开号：

EP1948135A4

申请日:

2006.10.26

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The invention relates to a controlled release composition comprising a combination of isosorbide dinitrate and hydralazine, such as hydralazine hydrochloride, that in operation delivers the drug in a pulsed or multi-modal manner for the treatment of angina, ischaemic heart disease, arterial hypertension and related disease conditions. Preferably, the isosorbide dinitrate and hydralazine hydrochloride can be released from the dosage form in an erodable, diffusion and/or osmotic-controlled release profile.

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