University of Pittsburgh- Of the Commonwealth System of Higher Education
发明人:
SHANKS, Robert, Michael Queen,KLARLUND, Jes, K.
申请号：
EP17853753
公开号：
EP3516063A4
申请日:
2017.09.19
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Pharmaceutical compositions are disclosed including an effective amount of a fusion protein that contains an anchor domain and a therapeutic polypeptide for use in treating a disorder that affects the eye (e.g., corneal haze or scarring, dry eye disease, and inflammation of an ocular surface). Fusion proteins are disclosed that includes an anchor domain and a therapeutic polypeptide. Some embodiments include an isolated nucleic acid molecule that can encode the fusion protein. Methods are also disclosed for treating a subject with a disorder that affects the eye (e.g., corneal haze or scarring, dry eye disease, and inflammation of an ocular surface) that includes administering to the eye of the subject a therapeutically effective amount of the fusion protein disclosed herein.
