The present invention provides antibody compositions, including, e.g., antibodies, engineered antibodies and antibody fragments that bind to a tumor necrosis factor receptor superfamily member (i.e., 18). Provided compositions are useful in enhancing CD4+ and CD8+ T cell responses, and in the treatment, amelioration and prevention of diseases that can be counteracted with an augmented immune response, e.g., cancers. Also provided in the invention are polynucleotides and vectors that encode such molecules and host cells that harbor the polynucleotides or vectors as well as pharmaceutical compositions that comprise such molecules and methods of use thereof.本發明提供抗體組合物,其包括例如結合於腫瘤壞死因子受體超家族成員(亦即18)的抗體、經工程改造之抗體及抗體片段。所提供之組合物適用於提高CD4+及CD8+ T細胞反應,及治療、改善及預防可藉由增強免疫反應來對抗的疾病,例如癌症。本發明亦提供編碼此類分子之聚核苷酸及載體及具有該等聚核苷酸或載體之宿主細胞;以及包含此類分子之醫藥組合物及其使用方法。
