您的位置: 首页 > 农业专利 > 详情页

METHOD FOR DETERMINING CLINICALLY SIGNIFICANT HYPOXIA IN CANCER
专利权人:
Орхус Университет (DK)
发明人:
ОВЕРГОР Енс (DK),СЕРЕНСЕН Брита Сингерс (DK),АЛЬСНЕР Ян (DK),ВИУФ Карстен (DK),НОРСМАРК Марианне (DK),ТОУСТРУП Каспер (DK)
申请号:
RU2013153096/10
公开号:
RU2013153096A
申请日:
2012.04.30
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A method for determining the oxygen status of cancer in an individual, comprising: i) in a sample comprising cells of said cancer, ii) determining the transcriptional level of expression of the ADM gene (SEQ ID NO: 1) or a variant that is at least 95% identical to it, iii ) correlation of the indicated transcriptional level of ADM gene expression with the expression level of at least one reference gene; and iv) assessment of the oxygen status of the cancer by comparing the correlated transcriptional expression level iii) with a predefined correlated trans scriptural expression level ADM.2. The method of claim 1, comprising: i) in a sample comprising cells of said cancer, ii) determining a transcriptional level of ADM expression and at least one additional gene selected from the group consisting of ANKRD37 (SEQ ID NO: 3), P4HA2 ( SEQ ID NO: 12), NDRG1 (SEQ ID NO: 10), SLC2A1 (SEQ ID NO: 15), P4HA1 (SEQ ID NO: 11), LOX (SEQ ID NO: 9), C3orf28 (SEQ ID NO: 6 ), BNIP3L (SEQ ID NO: 5), BNIP3 (SEQ ID NO: 4), EGLN3 (SEQ ID NO: 7), PDK1 (SEQ ID NO: 13), PFKFB3 (SEQ ID NO: 14), KCTD11 (SEQ ID NO: 8), ALDOA (SEQ ID NO: 2) and variants that are at least 95% identical to any of the indicated genes, iii) the correlation of the indicated transcriptional level of ADM gene expression and the specified at least at least one additional gene with an expression level of at least one reference gene, and iv) an assessment of the oxygen status of said cancer by comparing a correlated transcriptional expression level iii) with a predetermined correlated transcriptional expression level of ADM and said at least one additional gene. 3. The method of claim 1 or 2, wherein the transcriptional expression level is at least 2, preferably at least 3, more preferably m1. Способ определения кислородного статуса рака у индивида, включающий:i) в образце, включающем клетки указанного рака,ii) определение транскрипционного уровня экспрессии гена ADM (SEQ ID NO: 1) или варианта, по меньшей мере на 95%
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
相关专利

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充