Transcobalamin receptor polypeptides, nucleic acids and modulators thereof, and related methods used to regulate cell growth and to treat cancer and cobalamin deficiency

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专利权人:

ザ リサーチ ファウンデーション オブ ステイト ユニバーシティー オブ ニューヨーク

发明人:

クアドロス， エドワード ブイ．,セクエイラ， ジェフリー エム．,クアドロス, エドワード ブイ.,セクエイラ, ジェフリー エム.

申请号：

JP2009504337

公开号：

JP5524610B2

申请日:

2007.04.05

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The present invention provides the amino acid and polynucleotide sequences of the transcobalamin receptor, as well as modulators of the transcobalamin receptor. Accordingly, the present invention provides compositions and methods for the treatment and prevention of diseases and disorders associated with cobalamin deficiency, including compositions and methods that promote cobalamin uptake. In addition, the present invention provides compositions and methods for the detection, treatment, and prevention of diseases associated with deregulated cell growth, including, e.g., cancer and autoimmune disorders, including compositions and methods that inhibit cobalamin uptake.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/