David Ryall Brown,Ian Collins,Lloyd George Czaplewski,David John Haydon
申请号：
US12293608
公开号：
US08088791B2
申请日:
2007.03.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compounds of formula (I) have antibacterial activity:wherein R represents hydrogen or 1, 2 or 3 optional substituents W is ═C(R1)— or ═N— R1 is hydrogen or an optional substituent and R2 is hydrogen, methyl, or fluorine or R1 and R2 taken together are —CH2—, —CH2CH2—, —O—, or, in either orientation, —O—CH2— or —OCH2CH2— R3 is a radical of formula -(Alk1)m-(Z)p-(Alk2)n-Q wherein m, p and n are independently 0 or 1, provided that at least one of m, p and n is 1, Z is —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, —N(CH2CH3)—, —C(═O)—, —O—(C═O)—, —C(═O)—O—, or an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms or an optionally substituted divalent bicyclic heterocyclic radical having 5 to 10 ring atoms Alk1 and Alk2 are optionally substituted C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radicals, which may optionally terminate with or be interrupted by —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, or —N(CH2CH3)— and Q is hydrogen, halogen, nitrile, or hydroxyl or an optionally substituted monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms or an optionally substituted bicyclic heterocyclic radical having 5 to 10 ring atoms.
