process for the preparation of 6- (cyclopropanoamido) -4 - ((2-methoxy-3- (1-methyl-1h-1,2,4-triazol-3-yl) phenyl) amino) -n- (methyl- d3) pyridazine-3-carboxamide
AMANDA J. ROGERS,BAHAR INANKUR,BIN ZHENG,DANIEL S. TREITLER,DONG LIN,ERIC M. SIMMONS,JIANJI WANG,JOERG DEERBERG,JUN LI,KE CHEN,MAXIME C. D. SOUMEILLANT,MICHAEL DUMMELDINGER,MICHAEL J. SMITH,NEIL A. ST
申请号：
BR112019020169
公开号：
BR112019020169A2
申请日:
2018.03.29
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
the present invention relates to an improved process for the synthesis of 6- (cyclopropanoamido) -4 - ((2-methoxy-3- (1-methyl-1h-1,2,4-triazol-3-yl) phenyl ) amino) -n- (methyl-d3) pyridazine-3-carboxamide of the formula: (i) compound i is currently in clinical trials for the treatment of autoimmune and autoinflammatory diseases such as psoriasis.a presente invenção refere-se a um processo aperfeiçoado para a síntese de 6-(ciclopropanoamido)-4-((2-metóxi-3-(1-metil-1h-1,2,4-triazol-3-il)fenil)amino)-n-(metil-d3)piridazina-3-carboxamida da fórmula: (i) o composto i está atualmente em experiências clínicas para o tratamento de doenças autoimunes e autoinflamatórias tais como a psoríase.
