ЛИМ Хьюнг Кю (KR),КИМ Хьюн Ок (KR),ЛИ Ми Кьюнг (KR),ЛИ Чжонг Соо (KR),БЭ Сан Мин (KR),КВОН Се Чан (KR)
申请号：
RU2015104489
公开号：
RU2015104489A
申请日:
2013.07.25
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. The liquid composition of a combination of long-acting insulin and an insulinotropic peptide, comprising insulin and an insulinotropic peptide are physiologically active peptides and containing albumin stabilizer which comprises a buffer, a sugar alcohol, a nonionic surfactant and isotonic agent.2. The liquid composition according to Claim. 1, where insulin is the pharmaceutically effective amount of the long-acting insulin, wherein the insulin is linked to an immunoglobulin Fc-region and the insulinotropic peptide is a pharmaceutically effective amount of a long acting insulinotropic peptide conjugate, wherein the insulinotropic peptide is associated with Fc -domain immunoglobulina.3. The liquid composition according to Claim. 1, wherein the insulin has the same amino acid sequence as the native insulin.4. The liquid composition according to Claim. 1, wherein the insulin is an insulin derivative is obtained from native insulin by amino acid substitutions, deletions or insertions, or agonist peptide having a similar native insulin aktivnost.5. The liquid composition according to Claim. 1, wherein the insulinotropic peptide is selected from the group consisting of glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), exendin-3, exendin-4 and their precursors, agonists, derivatives, fragments and variants and their kombinatsiy.6. The liquid composition of claim. 5, wherein the variant peptide is an insulinotropic imidazoatsetileksendin-4.7. The liquid composition of claim. 2, wherein the Fc-region of an immunoglobulin is an Fc-region having the origin of IgG, IgA, IgD, IgE or IgM.8. The liquid composition of claim. 7, where the Fc-region of an immunoglobulin is1. Жидкая композиция комбинации длительно действующих инсулина и инсулинотропного пептида, содержащая инсулин и инсулинотропный пептид, являющиеся физиологически активными пептидами, и не содержащий альбумина стабилизатор, который содержит буфер, сахарный спирт, неионное поверхностно-активное веще
