The invention provides transcranial electrostimulation by combining transcranial direct current stimulation (tDCS) and theta burst stimulation (TBS) to achieve an unexpected therapeutic effect in various brain or neural diseases. Accordingly, the invention provides a mode of direct current with biphasic square wave pulses in the treatment of brain or neural diseases. Also provided are methods of employing the transcranial electrostimulation of the invention and applications of the transcranial electrostimulation of the invention.本發明藉由組合經顱直流電流刺激(tDCS)與θ陣發型刺激(TBS)提供經顱電刺激,以在各種腦病或神經疾病中達成意外治療效應。因此,本發明提供一種以直流電流與雙相方波脈衝治療腦病或神經疾病之模式。亦提供使用本發明之經顱電刺激之方法及本發明之經顱電刺激之應用。110‧‧‧經顱電刺激器120‧‧‧直流電流源122‧‧‧交流電流源130‧‧‧可撓性頭支撐架150‧‧‧電極組/電極總成150a‧‧‧第一電極150b‧‧‧第二電極S‧‧‧個體