1-(4-(isoxazol-5-YL)-1H-pyrazol-1-YL)-2-methylpropan-2-OL derivatives and related compounds as IL-17 and IFN-gamma inhibitors for treating autoimmune diseases and chronic inflammation
FELDING, Jakob,KOHLHOF, Hella,GRÖPPEL, Manfred,MÜHLER, Rolf Andreas,VITT, Daniel,CHEVRIER, Carine,ZAJA, Mirko,TASLER, Stefan
申请号：
AU2018330633
公开号：
AU2018330633A1
申请日:
2018.09.06
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein Ar, Z and Y are as described herein and R1 is a group of the structure (formula (II)), wherein n is 0 or 1； R2 is H, deuterium or methyl； R3 is methyl, trilluoromethyl, ethyl, or taken with R2 together forms a cyclopropyl group, or R3 forms a methylene bridge to the carbon atom marked *, which are suitable for the treatment of autoimmune diseases and chronic inflammation.
