THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人:
HERGENROTHER, PAUL J.,PARKINSON, ELIZABETH I.,BAIR, JOSEPH S.
申请号：
CA2943204
公开号：
CA2943204A1
申请日:
2015.03.17
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Compounds that specifically kill fluoroquinolone (FQ) resistant bacteria have been developed and are described herein. The FQs are the most commonly prescribed antibiotics to adults in the U.S. and thus are extremely important drugs. However, bacterial resistant to these drugs is now ubiquitous in some of the most common and deadly Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Indeed, FQs are no longer indicated for treatment of MRSA and VRE infections because of such resistance. The compounds have specific and potent activity versus MRSA and VRE.
